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Study Information
Study Attribute Value
CEBS Accession Number: 002-01465-0001-0000-9
Chemical Name: 4,4'-Methylenebis(2-chloroaniline)
CASRN: 101-14-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 845170_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/13/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 445 0.425 8.90 26.0 0.000
Test Chemical 4,4'-Methylenebis(2-chloroaniline) 
 0.003     
 50 1048 420 0.401 8.40 26.0 -5.708 
 0.03      
 50 1045 448 0.429 8.96 26.0 0.867 
 0.3       
 50 1049 406 0.387 8.12 26.0 -8.938 
3         
 50 1045 467 0.447 9.34 26.0 5.145 
30         
 25 521 246 0.472 9.84 26.0 11.092
Positive Control Triethylenemelamine 
 0.025     
 50 1046 2295 2.194 45.90 26.0 416.223
Trend: 1.378        
Probability: 0.084        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/13/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 436 0.416 8.72 26.0 0.000
Test Chemical 4,4'-Methylenebis(2-chloroaniline) 
 0.003     
 50 1050 428 0.408 8.56 26.0 -2.115 
 0.03      
 50 1049 435 0.415 8.70 26.0 -0.420 
 0.3       
 50 1050 415 0.395 8.30 26.0 -5.088 
3         
 50 1050 460 0.438 9.20 26.0 5.203 
30         
 50 1050 506 0.482 10.12 26.0 15.723
Positive Control Cyclophosphamide 
1.5       
 50 1049 1624 1.548 32.48 26.0 271.767
Trend: 2.371        
Probability: 0.009