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Study Information
Study Attribute Value
CEBS Accession Number: 002-01465-0002-0000-0
Chemical Name: 4,4'-Methylenebis(2-chloroaniline)
CASRN: 101-14-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 845170_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/13/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4'-Methylenebis(2-chloroaniline) 
 0.003     
 100 8 0.080 6.0 1 0.010 1.0 7 0.070 5.0 0 0.000 0.0 
 0.03      
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
 0.3       
 100 4 0.040 1.0 0 0.000 0.0 4 0.040 1.0 0 0.000 0.0 
3         
 100 6 0.060 2.0 0 0.000 0.0 6 0.060 2.0 0 0.000 0.0 
30         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 43 0.430 29.0 15 0.150 15.0 28 0.280 22.0 0 0.000 0.0
Trend: 0.148 0.415 0.000  
Probability: 0.441 0.339 0.500  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/13/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 4,4'-Methylenebis(2-chloroaniline) 
 0.003     
 100 5 0.050 3.0 1 0.010 1.0 4 0.040 2.0 0 0.000 0.0 
 0.03      
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
 0.3       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
3         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0 
30         
 100 6 0.060 4.0 2 0.020 2.0 4 0.040 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 114 1.140 59.0 45 0.450 36.0 67 0.670 41.0 2 0.020 1.0
Trend: 0.841 1.446 0.082  
Probability: 0.200 0.074 0.467