Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01465-0003-0000-1 |
Chemical Name: | 4,4'-Methylenebis(2-chloroaniline) |
CASRN: | 101-14-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 948170_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Questionable |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1032 | 311 | 0.301 | 6.22 | 26.5 | 0.388 |
Dimethyl Sulfoxide | 0 | 50 | 1036 | 311 | 0.300 | 6.22 | 26.5 | 0.000 | |
Test Chemical | 4,4'-Methylenebis(2-chloroaniline) | 0.005 | 50 | 1043 | 316 | 0.303 | 6.32 | 26.5 | 0.926 |
0.05 | 50 | 1032 | 422 | 0.409 | 8.44 | 26.5 | 36.217 | ||
0.5 | 50 | 1036 | 376 | 0.363 | 7.52 | 26.5 | 20.900 | ||
5 | 50 | 1035 | 406 | 0.392 | 8.12 | 26.5 | 30.673 | ||
Positive Control | Triethylenemelamine | 0.015 | 50 | 1026 | 1140 | 1.111 | 22.80 | 26.5 | 270.132 |
Trend: | 4.184 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1044 | 450 | 0.431 | 9.00 | 26.5 | -1.667 |
Dimethyl Sulfoxide | 0 | 50 | 1038 | 455 | 0.438 | 9.10 | 26.5 | 0.000 | |
Test Chemical | 4,4'-Methylenebis(2-chloroaniline) | 0.08 | 50 | 1047 | 469 | 0.448 | 9.38 | 26.5 | 2.191 |
0.4 | 50 | 1042 | 456 | 0.438 | 9.12 | 26.5 | -0.165 | ||
2 | 50 | 1037 | 431 | 0.416 | 8.62 | 26.5 | -5.183 | ||
10 | 50 | 1044 | 465 | 0.445 | 9.30 | 26.5 | 1.610 | ||
50 | 50 | 1036 | 560 | 0.541 | 11.20 | 28.0 | 23.315 | ||
Positive Control | Cyclophosphamide | 1.5 | 50 | 1037 | 1512 | 1.458 | 30.24 | 26.5 | 232.628 |
Trend: | 2.745 | ||||||||
Probability: | 0.003 |