COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01465-0003-0000-1
Chemical Name: 4,4'-Methylenebis(2-chloroaniline)
CASRN: 101-14-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 948170_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 10/27/1980    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1032 311 0.301 6.22 26.5 0.388
Dimethyl Sulfoxide
0         
50 1036 311 0.300 6.22 26.5 0.000
Test Chemical 4,4'-Methylenebis(2-chloroaniline)
 0.005     
50 1043 316 0.303 6.32 26.5 0.926
 0.05      
50 1032 422 0.409 8.44 26.5 36.217
 0.5       
50 1036 376 0.363 7.52 26.5 20.900
5         
50 1035 406 0.392 8.12 26.5 30.673
Positive Control Triethylenemelamine
 0.015     
50 1026 1140 1.111 22.80 26.5 270.132
Trend: 4.184        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/05/1980    Trial Call: Questionable   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1044 450 0.431 9.00 26.5 -1.667
Dimethyl Sulfoxide
0         
50 1038 455 0.438 9.10 26.5 0.000
Test Chemical 4,4'-Methylenebis(2-chloroaniline)
 0.08      
50 1047 469 0.448 9.38 26.5 2.191
 0.4       
50 1042 456 0.438 9.12 26.5 -0.165
2         
50 1037 431 0.416 8.62 26.5 -5.183
10         
50 1044 465 0.445 9.30 26.5 1.610
50         
50 1036 560 0.541 11.20 28.0 23.315
Positive Control Cyclophosphamide
1.5       
50 1037 1512 1.458 30.24 26.5 232.628
Trend: 2.745        
Probability: 0.003