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Study Information
Study Attribute Value
CEBS Accession Number: 002-01465-0004-0000-2
Chemical Name: 4,4'-Methylenebis(2-chloroaniline)
CASRN: 101-14-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 948170_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/02/1980    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4'-Methylenebis(2-chloroaniline)
 0.005     
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
 0.05      
100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
 0.5       
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
5         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Triethylenemelamine
 0.25      
100 82 0.820 49.0 26 0.260 20.0 55 0.550 36.0 1 0.010 1.0
Trend: 0.000 0.000 0.000  
Probability: 0.500 0.000 0.500  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/30/1980    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4'-Methylenebis(2-chloroaniline)
 0.005     
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
 0.05      
100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
 0.5       
100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
5         
100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide
25         
100 54 0.540 37.0 21 0.210 18.0 32 0.320 25.0 1 0.010 1.0
Trend: 0.994 1.452 -0.290  
Probability: 0.160 0.073 0.614