Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01465-0016-0000-5 |
Chemical Name: | 4,4'-Methylenebis(2-chloroaniline) |
CASRN: | 101-14-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | G87947 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 103 | 98 | 93 | 30 | 34 |
108 | 102 | 121 | 38 | ||||
Test Chemical | 4,4'-Methylenebis(2-chloroaniline) | 51.7 | 112 | 64 | 165 | 49 | 49 |
95 | 55 | 138 | 48 | ||||
63.8 | 111 | 75 | 173 | 52 | 48 | ||
110 | 68 | 143 | 43 | ||||
78.7 | 104 | 49 | 149 | 48 | 49 | ||
98 | 33 | 151 | 51 | ||||
87.5 | 95 | 28 | 129 | 45 | 46 | ||
95 | 24 | 131 | 46 | ||||
97.2 | 85 | 12 | 81 | 32 | 40 | ||
91 | 12 | 131 | 48 | ||||
108 | |||||||
Positive Control | Ethyl Methane Sulfonate | 500 | 63 | 35 | 963 | 508 | 502* |
62 | 37 | 919 | 497 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 98 | 106 | 92 | 31 | 31 |
90 | 94 | 84 | 31 | ||||
Test Chemical | 4,4'-Methylenebis(2-chloroaniline) | 41.8 | 84 | 78 | 78 | 31 | 37 |
86 | 77 | 113 | 44 | ||||
51.6 | 93 | 77 | 99 | 35 | 43 | ||
84 | 69 | 129 | 51 | ||||
63.7 | 90 | 52 | 133 | 49 | 43 | ||
103 | 70 | 114 | 37 | ||||
78.7 | 79 | 28 | 104 | 44 | 48 | ||
85 | 30 | 130 | 51 | ||||
87.5 | 85 | 17 | 97 | 38 | |||
97.2 | |||||||
56 | 3 | 146 | 87 | ||||
108 | |||||||
Positive Control | Ethyl Methane Sulfonate | 500 | 55 | 34 | 1003 | 612 | 656* |
48 | 34 | 1008 | 700 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 111 | 105 | 48 | 14 | 18 |
106 | 95 | 67 | 21 | ||||
Test Chemical | 4,4'-Methylenebis(2-chloroaniline) | 5.4 | 99 | 99 | 64 | 22 | 22 |
107 | 105 | 72 | 23 | ||||
9.1 | 107 | 96 | 49 | 15 | 20 | ||
104 | 95 | 78 | 25 | ||||
15.1 | 92 | 73 | 80 | 29 | 26 | ||
102 | 85 | 71 | 23 | ||||
25.2 | 103 | 78 | 69 | 22 | 25 | ||
104 | 72 | 90 | 29 | ||||
42 | 90 | 48 | 118 | 44 | 39* | ||
81 | 43 | 81 | 33 | ||||
70 | 62 | 23 | 122 | 66 | 67* | ||
75 | 27 | 151 | 67 | ||||
Positive Control | 3-Methylcholanthrene | 6 | 38 | 17 | 404 | 356 | 278* |
59 | 26 | 352 | 199 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 90 | 101 | 232 | 86 | 92 |
94 | 99 | 274 | 97 | ||||
Test Chemical | 4,4'-Methylenebis(2-chloroaniline) | 3.3 | 96 | 106 | 259 | 90 | 103 |
84 | 95 | 295 | 117 | ||||
5.4 | 91 | 85 | 312 | 114 | 117 | ||
83 | 89 | 298 | 120 | ||||
9.1 | 81 | 80 | 284 | 117 | 115 | ||
98 | 85 | 329 | 112 | ||||
15.1 | 90 | 59 | 367 | 135 | 135 | ||
79 | 55 | 319 | 135 | ||||
25.2 | 62 | 22 | 384 | 205 | 195* | ||
72 | 24 | 399 | 185 | ||||
42 | 46 | 5 | 437 | 317 | 324* | ||
42 | 5 | 418 | 332 | ||||
70 | |||||||
Positive Control | 3-Methylcholanthrene | 5 | 47 | 23 | 492 | 351 | 357* |
44 | 23 | 473 | 362 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination