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Study Information
Study Attribute Value
CEBS Accession Number: 002-01466-0001-0000-0
Chemical Name: 4,4'-Methylenebis(N,N-dimethyl)benzenamine
CASRN: 101-61-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 553210_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/12/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1027 485 0.472 9.70 25.6 0.000
Test Chemical 4,4'-Methylenebis(N,N-dimethyl)benzenamine 
 0.05      
 50 1030 370 0.359 7.40 25.6 -23.934 
 0.167     
 50 1034 378 0.366 7.56 25.6 -22.589 
 0.5       
 50 1019 403 0.395 8.06 25.6 -16.255 
1.7       
 10 213 117 0.549 11.70 25.6 16.315 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1026 717 0.699 14.34 25.6 47.979
Mitomycin-C 
 0.01      
 5 106 228 2.151 45.60 25.6 355.468
Trend: -0.749        
Probability: 0.773        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/12/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1011 409 0.405 8.18 25.6 0.000
Test Chemical 4,4'-Methylenebis(N,N-dimethyl)benzenamine 
1.7       
 50 1006 450 0.447 9.00 25.6 10.571 
5         
 50 1009 462 0.458 9.24 25.6 13.182 
16.7       
 50 1016 437 0.430 8.74 25.6 6.320 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 837 0.809 16.74 25.6 99.900
Cyclophosphamide 
2         
 5 105 222 2.114 44.40 25.6 422.627
Trend: 0.912        
Probability: 0.181