Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01466-0001-0000-0 |
Chemical Name: | 4,4'-Methylenebis(N,N-dimethyl)benzenamine |
CASRN: | 101-61-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 553210_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 50 | 1027 | 485 | 0.472 | 9.70 | 25.6 | 0.000 |
Test Chemical | 4,4'-Methylenebis(N,N-dimethyl)benzenamine | 0.05 | 50 | 1030 | 370 | 0.359 | 7.40 | 25.6 | -23.934 |
0.167 | 50 | 1034 | 378 | 0.366 | 7.56 | 25.6 | -22.589 | ||
0.5 | 50 | 1019 | 403 | 0.395 | 8.06 | 25.6 | -16.255 | ||
1.7 | 10 | 213 | 117 | 0.549 | 11.70 | 25.6 | 16.315 | ||
5 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1026 | 717 | 0.699 | 14.34 | 25.6 | 47.979 |
Mitomycin-C | 0.01 | 5 | 106 | 228 | 2.151 | 45.60 | 25.6 | 355.468 | |
Trend: | -0.749 | ||||||||
Probability: | 0.773 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 50 | 1011 | 409 | 0.405 | 8.18 | 25.6 | 0.000 |
Test Chemical | 4,4'-Methylenebis(N,N-dimethyl)benzenamine | 1.7 | 50 | 1006 | 450 | 0.447 | 9.00 | 25.6 | 10.571 |
5 | 50 | 1009 | 462 | 0.458 | 9.24 | 25.6 | 13.182 | ||
16.7 | 50 | 1016 | 437 | 0.430 | 8.74 | 25.6 | 6.320 | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1035 | 837 | 0.809 | 16.74 | 25.6 | 99.900 |
Cyclophosphamide | 2 | 5 | 105 | 222 | 2.114 | 44.40 | 25.6 | 422.627 | |
Trend: | 0.912 | ||||||||
Probability: | 0.181 |