Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01466-0002-0000-1 |
Chemical Name: | 4,4'-Methylenebis(N,N-dimethyl)benzenamine |
CASRN: | 101-61-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 553210_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 7 | 0.035 | 3.0 | 5 | 0.025 | 2.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Acetone | 0 | 200 | 7 | 0.035 | 3.5 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | 4,4'-Methylenebis(N,N-dimethyl)benzenamine | 101 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
150 | 200 | 4 | 0.020 | 2.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
200 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 50 | 43 | 0.860 | 50.0 | 20 | 0.400 | 30.0 | 23 | 0.460 | 36.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 25 | 1.000 | 52.0 | 12 | 0.480 | 40.0 | 13 | 0.520 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.943 | -0.218 | -1.458 | ||||||||||||
Probability: | 0.827 | 0.586 | 0.928 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Acetone | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 4,4'-Methylenebis(N,N-dimethyl)benzenamine | 101 | 200 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
150 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
200 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 6.25 | 200 | 25 | 0.125 | 10.5 | 6 | 0.030 | 2.5 | 19 | 0.095 | 8.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 11 | 0.440 | 40.0 | 3 | 0.120 | 12.0 | 8 | 0.320 | 32.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.435 | -1.331 | 0.580 | ||||||||||||
Probability: | 0.668 | 0.908 | 0.281 |