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Study Information
Study Attribute Value
CEBS Accession Number: 002-01468-0001-0000-2
Chemical Name: 4,4'-Oxydianiline
CASRN: 101-80-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 235006_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/28/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 402 0.385 8.04 26.5 -2.471
Dimethyl Sulfoxide 
0         
 50 1041 411 0.395 8.22 26.5 0.000
Test Chemical 4,4'-Oxydianiline 
5         
 50 1040 426 0.410 8.52 26.5 3.749 
16         
 50 1031 463 0.449 9.26 26.5 13.745 
50         
 50 1039 632 0.608 12.64 26.5 54.067 
160         
 0 0 0 0.000 0.00 0.0 N/A 
500         
 0 0 0 0.000 0.00 0.0 N/A 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1047 1448 1.383 28.96 26.5 250.292
Trend: 7.175        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/05/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 377 0.362 7.54 28.5 -0.362
Dimethyl Sulfoxide 
0         
 50 1052 382 0.363 7.64 28.5 0.000
Test Chemical 4,4'-Oxydianiline 
100         
 0 0 0 0.000 0.00 0.0 N/A 
250         
 50 1046 1505 1.439 30.10 40.5 296.239 
500         
 0 0 0 0.000 0.00 0.0 N/A 
750         
 0 0 0 0.000 0.00 0.0 N/A 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1047 1647 1.573 32.94 28.5 333.211
Trend: 25.976        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 06/10/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 371 0.360 7.42 26.5 0.000
Negative (Not Specified) 
0         
 50 1041 395 0.379 7.90 26.5 5.344
Test Chemical 4,4'-Oxydianiline 
50         
 50 1032 731 0.708 14.62 34.0 96.653 
150         
 50 1042 1323 1.270 26.46 34.0 252.497 
200         
 50 1034 1572 1.520 31.44 44.0 322.081 
300         
 50 1041 1668 1.602 33.36 44.0 344.845 
400         
 50 1041 1861 1.788 37.22 44.0 396.317 
500         
 50 1041 1757 1.688 35.14 44.0 368.581
Positive Control Mitomycin-C 
 0.01      
 50 1019 2211 2.170 44.22 26.5 502.390
Trend: 37.096        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/28/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1026 399 0.389 7.98 26.5 -7.661
Dimethyl Sulfoxide 
0         
 50 1040 438 0.421 8.76 26.5 0.000
Test Chemical 4,4'-Oxydianiline 
160         
 50 1039 440 0.423 8.80 26.5 0.553 
500         
 50 1021 475 0.465 9.50 26.5 10.466 
1600         
 50 1045 582 0.557 11.64 26.5 32.241 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1040 1369 1.316 27.38 26.5 212.557
Trend: 4.757        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/05/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 380 0.362 7.60 26.5 0.000
Negative (Not Specified) 
0         
 50 1046 368 0.352 7.36 26.5 -2.695
Test Chemical 4,4'-Oxydianiline 
500         
 50 1035 463 0.447 9.26 26.5 23.726 
1000         
 0 0 0 0.000 0.00 26.5 N/A 
2000         
 50 1034 448 0.433 8.96 26.5 19.833 
3000         
 50 1042 552 0.530 11.04 26.5 46.518 
4000         
 50 1029 551 0.535 11.02 26.5 48.100 
5000         
 27 560 479 0.855 17.74 26.5 136.574
Positive Control Cyclophosphamide 
1.5       
 50 1047 949 0.906 18.98 26.5 150.691
Trend: 10.136        
Probability: 0.000