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Study Information
Study Attribute Value
CEBS Accession Number: 002-01468-0002-0000-3
Chemical Name: 4,4'-Oxydianiline
CASRN: 101-80-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 235006_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Positive 
No Activation  3  Questionable 
Induced Rat Liver S9  3_S9  Positive 

Trial #:1   Activation: No Activation    Date: 04/26/1983    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 4,4'-Oxydianiline 
100         
 100 17 0.170 13.0 2 0.020 2.0 15 0.150 13.0 0 0.000 0.0 
500         
 100 32 0.320 16.0 8 0.080 2.0 23 0.230 16.0 1 0.010 1.0 
1000         
 100 55 0.550 24.0 7 0.070 6.0 47 0.470 22.0 1 0.010 1.0 
2000         
 100 21 0.210 11.0 2 0.020 2.0 9 0.090 8.0 10 0.100 1.0 
3000         
 100 22 0.220 17.0 11 0.110 10.0 11 0.110 8.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 129 1.290 68.0 69 0.690 52.0 60 0.600 44.0 0 0.000 0.0
Trend: 2.613 2.366 1.421  
Probability: 0.004 0.009 0.078  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/26/1983    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4'-Oxydianiline 
500         
 100 8 0.080 7.0 4 0.040 3.0 4 0.040 4.0 0 0.000 0.0 
1000         
 100 12 0.120 7.0 6 0.060 3.0 6 0.060 5.0 0 0.000 0.0 
2000         
 100 16 0.160 13.0 9 0.090 8.0 7 0.070 7.0 0 0.000 0.0 
3000         
 100 29 0.290 15.0 10 0.100 8.0 9 0.090 6.0 10 0.100 1.0 
4000         
 100 18 0.180 16.0 8 0.080 7.0 10 0.100 9.0 0 0.000 0.0 
5000         
 100 29 0.290 20.0 23 0.230 15.0 5 0.050 5.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 100 55 0.550 38.0 27 0.270 24.0 28 0.280 23.0 0 0.000 0.0
Trend: 4.937 4.079 2.448  
Probability: 0.000 0.000 0.007  


Trial #:2   Activation: No Activation    Date: 04/26/1983    Harvest Time: 17.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 4,4'-Oxydianiline 
100         
 100 36 0.360 12.0 6 0.060 5.0 10 0.100 7.0 20 0.200 2.0 
500         
 100 53 0.530 32.0 25 0.250 16.0 25 0.250 18.0 3 0.030 3.0 
1000         
 66 49 0.742 42.0 13 0.197 17.0 23 0.348 23.0 13 0.197 6.0 
2000         
 100 38 0.380 24.0 24 0.240 17.0 14 0.140 11.0 0 0.000 0.0 
3000         
 100 23 0.230 16.0 8 0.080 8.0 15 0.150 10.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 129 1.290 68.0 69 0.690 52.0 60 0.600 44.0 0 0.000 0.0
Trend: 4.025 3.246 2.739  
Probability: 0.000 0.001 0.003  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/26/1983    Harvest Time: 16.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4'-Oxydianiline 
500         
 100 7 0.070 4.0 4 0.040 2.0 3 0.030 3.0 0 0.000 0.0 
2000         
 100 30 0.300 17.0 16 0.160 10.0 13 0.130 10.0 1 0.010 1.0 
3000         
 100 18 0.180 10.0 9 0.090 4.0 9 0.090 8.0 0 0.000 0.0 
4000         
 100 16 0.160 11.0 11 0.110 8.0 5 0.050 5.0 0 0.000 0.0 
5000         
 100 31 0.310 20.0 27 0.270 18.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 76 0.760 48.0 37 0.370 32.0 38 0.380 33.0 1 0.010 1.0
Trend: 4.513 4.186 2.241  
Probability: 0.000 0.000 0.013  


Trial #:3   Activation: No Activation    Date: 03/30/1983    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4'-Oxydianiline 
50         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
160         
 100 11 0.110 9.0 8 0.080 6.0 2 0.020 2.0 1 0.010 1.0 
500         
 100 5 0.050 3.0 2 0.020 1.0 3 0.030 2.0 0 0.000 0.0 
1000         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
1600         
 100 11 0.110 6.0 3 0.030 3.0 8 0.080 4.0 0 0.000 0.0 
2000         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 37 0.370 26.0 15 0.150 14.0 22 0.220 18.0 0 0.000 0.0
Trend: 0.238 0.254 0.302  
Probability: 0.406 0.400 0.381  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 03/30/1983    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 4,4'-Oxydianiline 
160         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
500         
 100 20 0.200 16.0 6 0.060 6.0 13 0.130 9.0 1 0.010 1.0 
1600         
 100 45 0.450 18.0 28 0.280 13.0 17 0.170 10.0 0 0.000 0.0 
5000         
 100 12 0.120 9.0 5 0.050 4.0 6 0.060 5.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 100 79 0.790 34.0 30 0.300 22.0 19 0.190 15.0 30 0.300 3.0
Trend: 2.740 2.104 1.925  
Probability: 0.003 0.018 0.027