Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01468-0010-0000-2
Chemical Name:	4,4'-Oxydianiline
CASRN:	101-80-4
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	888699
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	84	104	92	37	34
			86	98	92	36
			91	100	85	31
			78	98	77	33
Test Chemical	4,4'-Oxydianiline	15.625	75	82	82	36	35
			94	98	97	34	35
		31.25	75	93	46	20	31
			75	93	93	42	31
		62.5	89	60	156	58	55*
			83	65	131	53	55*
		125	68	28	184	90	100*
			73	25	240	109	100*
		250	27	2	122	152	105*
			93	7	164	59	105*
		500

Positive Control	Methyl Methane Sulfonate	15	32	23	138	143	156*
			28	19	139	168	156*
	Methyl Methane Sulfonate	250	73	70	477	219	336*
			28	27	379	454	336*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	112	111	106	32	32
			93	101	101	36
			95	100	74	26
			94	88	94	33
Test Chemical	4,4'-Oxydianiline	50	80	102	157	66	59*
			87	76	137	53	59*
		100	72	40	382	178	179*
			73	39	393	181	179*
		150	35	7	406	390	413*
			32	4	411	435	413*
		200	9r	1	119	467
			8r	1	135	551
		250

		300

Positive Control	Methyl Methane Sulfonate	15	41	27	216	178	154*
			51	26	200	130	154*
	Methyl Methane Sulfonate	250	70	77	427	203	235*
			51	56	405	266	235*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination