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Study Information
Study Attribute Value
CEBS Accession Number: 002-01468-0011-0000-3
Chemical Name: 4,4'-Oxydianiline
CASRN: 101-80-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 227174_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/28/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.77 ± 0.301
Test Chemical 4,4'-Oxydianiline 
75         
 4 6.11 ± 0.476
  
150         
 4 6.24 ± 0.479
  
300         
 4 5.38 ± 0.578
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.05 ± 0.714


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/13/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.16 ± 0.186
Test Chemical 4,4'-Oxydianiline 
75         
 4 5.80 ± 0.396
  
150         
 4 6.14 ± 0.771
  
300         
 3 5.67 ± 0.741
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.83 ± 0.677


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/28/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.15 ± 0.261
Test Chemical 4,4'-Oxydianiline 
150         
 4 5.29 ± 0.454
  
225         
 4 5.47 ± 0.121
  
300         
 4 4.93 ± 0.408
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.82 ± 0.525


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed