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Study Information
Study Attribute Value
CEBS Accession Number: 002-01468-0012-0000-4
Chemical Name: 4,4'-Oxydianiline
CASRN: 101-80-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 227174_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/21/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2960
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 9.75 ± 1.28 0.0000
Test Chemical 4,4'-Oxydianiline 
125         
 8 0.75 ± 0.37 0.6479
  
250         
 8 1.25 ± 0.37 0.3687
  
500         
 8 1.25 ± 0.65 0.3687
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/04/86 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0042
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 6 18.33 ± 2.44 0.0000
Test Chemical 4,4'-Oxydianiline 
375         
 6 8.00 ± 3.18 0.0004
  
500         
 2 4.00 ± 0.00 0.2080
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.63 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/23/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0104
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 15.25 ± 2.33 0.0000
Test Chemical 4,4'-Oxydianiline 
87.5       
 8 1.25 ± 0.53 0.5000
  
175         
 8 1.50 ± 0.50 0.3807
  
350         
 8 3.25 ± 1.31 0.0282
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.65 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed