COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01468-0014-0000-6
Chemical Name: 4,4'-Oxydianiline
CASRN: 101-80-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 774801_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/20/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0111
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.25 ± 2.96 0.0000
Test Chemical 4,4'-Oxydianiline 
125         
 8 1.75 ± 0.59 0.7690
  
250         
 8 3.75 ± 1.39 0.1548
  
500         
 8 4.75 ± 1.25 0.0443
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/16/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0001
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 6.00 ± 1.69 0.0004
Test Chemical 4,4'-Oxydianiline 
250         
 8 0.75 ± 0.37 0.8427
  
500         
 8 5.75 ± 1.16 0.0007
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.63 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed