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Study Information
Study Attribute Value
CEBS Accession Number: 002-01469-0001-0000-3
Chemical Name: 4,4'-Sulfonyldianiline (Dapsone)
CASRN: 80-08-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 954704_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/17/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 386 0.369 7.72 26.0 3.565
Dimethyl Sulfoxide 
0         
 50 1045 372 0.356 7.44 26.0 0.000
Test Chemical 4,4'-Sulfonyldianiline (Dapsone) 
17         
 50 1043 359 0.344 7.18 26.0 -3.310 
50         
 50 1048 365 0.348 7.30 26.0 -2.163 
167         
 50 1047 402 0.384 8.04 26.0 7.858 
500         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 579 0.554 11.58 26.0 55.645
Mitomycin-C 
 0.004     
 10 211 237 1.123 23.70 26.0 215.529
Trend: 1.086        
Probability: 0.139        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/17/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 389 0.372 7.78 26.0 0.000
Negative (Not Specified) 
0         
 50 1052 356 0.338 7.12 26.0 -9.092
Test Chemical 4,4'-Sulfonyldianiline (Dapsone) 
50         
 50 1048 418 0.399 8.36 26.0 7.147 
167         
 50 1045 393 0.376 7.86 26.0 1.028 
500         
 50 1043 392 0.376 7.84 26.0 0.964 
1667         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1047 545 0.521 10.90 26.0 39.835
Cyclophosphamide 
 0.5       
 10 209 239 1.144 23.90 26.0 207.198
Trend: -0.142        
Probability: 0.556