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Study Information
Study Attribute Value
CEBS Accession Number: 002-01469-0002-0000-4
Chemical Name: 4,4'-Sulfonyldianiline (Dapsone)
CASRN: 80-08-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 954704_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Questionable 

Trial #:1   Activation: No Activation    Date: 05/07/1991    Harvest Time: 15.2 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4'-Sulfonyldianiline (Dapsone) 
465         
 200 4 0.020 1.0 0 0.000 0.0 4 0.020 1.0 0 0.000 0.0 
750         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1000         
 200 22 0.110 5.5 7 0.035 1.5 15 0.075 5.0 0 0.000 0.0 
1250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 19 0.760 44.0 8 0.320 28.0 11 0.440 28.0 0 0.000 0.0
Trend: 3.690 2.227 3.435  
Probability: 0.000 0.013 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/14/1990    Harvest Time: 12.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4'-Sulfonyldianiline (Dapsone) 
151         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
324         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
698         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 20 0.800 40.0 9 0.360 24.0 11 0.440 24.0 0 0.000 0.0
Trend: 1.293 1.375 0.610  
Probability: 0.098 0.084 0.271  


Trial #:2   Activation: No Activation    Date: 11/13/1990    Harvest Time: 15.2 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4'-Sulfonyldianiline (Dapsone) 
216         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
465         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
1000         
 200 9 0.045 3.5 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 34 1.360 64.0 12 0.480 48.0 11 0.440 24.0 11 0.440 8.0
Trend: 1.919 0.602 2.448  
Probability: 0.027 0.274 0.007