COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01469-0003-0000-5
Chemical Name: 4,4'-Sulfonyldianiline (Dapsone)
CASRN: 80-08-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 962654_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Test Failure 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/07/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1055 468 0.444 9.36 25.7 0.000
Test Chemical 4,4'-Sulfonyldianiline (Dapsone) 
167         
 50 1049 547 0.521 10.94 25.7 17.549 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 700 0.667 14.00 25.7 50.428
Mitomycin-C 
 0.01      
 5 107 278 2.598 55.60 25.7 485.690
Trend: 2.571        
Probability: 0.005        

Trial #: 2    Activation: No Activation    Date: 12/15/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 497 0.475 9.94 25.7 0.000
Test Chemical 4,4'-Sulfonyldianiline (Dapsone) 
300         
 50 1039 652 0.628 13.04 35.2 32.071 
350         
 50 1041 733 0.704 14.66 35.2 48.193 
400         
 50 1040 753 0.724 15.06 35.2 52.383
Positive Control Mitomycin-C 
 0.001     
 50 1049 695 0.663 13.90 25.7 39.439
Mitomycin-C 
 0.01      
 5 105 302 2.876 60.40 25.7 505.331
Trend: 7.517        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/07/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1053 486 0.462 9.72 25.7 0.000
Test Chemical 4,4'-Sulfonyldianiline (Dapsone) 
500         
 50 1054 462 0.438 9.24 25.7 -5.028 
1670         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1047 654 0.625 13.08 25.7 35.339
Cyclophosphamide 
2         
 5 105 163 1.552 32.60 25.7 236.349
Trend: -0.794        
Probability: 0.786        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 450 0.434 9.00 25.7 0.000
Test Chemical 4,4'-Sulfonyldianiline (Dapsone) 
700         
 50 1048 511 0.488 10.22 25.7 12.472 
800         
 50 1047 498 0.476 9.96 25.7 9.715 
900         
 50 1045 534 0.511 10.68 25.7 17.872 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1048 659 0.629 13.18 25.7 45.047
Cyclophosphamide 
2         
 5 104 173 1.663 34.60 25.7 283.705
Trend: 2.272        
Probability: 0.012