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Study Information
Study Attribute Value
CEBS Accession Number: 002-01469-0004-0000-6
Chemical Name: 4,4'-Sulfonyldianiline (Dapsone)
CASRN: 80-08-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 962654_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/04/1983    Harvest Time: 23 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 4.0 2 0.020 2.0 5 0.050 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: 4,4'-Sulfonyldianiline (Dapsone) 
300         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
400         
 100 10 0.100 9.0 3 0.030 3.0 7 0.070 7.0 0 0.000 0.0 
500         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0 
800         
 100 135 1.350 39.0 4 0.040 4.0 55 0.550 24.0 76 0.760 13.0
Positive Control: Mitomycin-C 
 0.0625    
 50 52 1.040 58.0 27 0.540 40.0 25 0.500 36.0 0 0.000 0.0
Trend: 7.751 0.277 6.663  
Probability: 0.000 0.391 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/04/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 6.0 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4'-Sulfonyldianiline (Dapsone) 
200         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
400         
 100 5 0.050 5.0 0 0.000 0.0 4 0.040 4.0 1 0.010 1.0 
600         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
800         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 13 0.260 22.0 7 0.140 12.0 6 0.120 10.0 0 0.000 0.0
Trend: 0.168 -1.323 0.215  
Probability: 0.433 0.907 0.415