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Study Information
Study Attribute Value
CEBS Accession Number: 002-01470-0001-0000-5
Chemical Name: 4,4'-Thiodianiline
CASRN: 139-65-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 915540_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 08/05/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 383 0.366 7.66 26.0 0.000
Test Chemical 4,4'-Thiodianiline 
1.6       
 50 1048 376 0.359 7.52 26.0 -1.921 
5         
 50 1050 443 0.422 8.86 26.0 15.335 
16         
 50 1050 470 0.448 9.40 26.0 22.365 
50         
 41 860 486 0.565 11.85 26.0 54.485
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 509 0.485 10.18 26.0 32.518
Mitomycin-C 
 0.005     
 10 210 289 1.376 28.90 26.0 276.207
Trend: 7.128        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 424 0.403 8.48 26.0 0.000
Test Chemical 4,4'-Thiodianiline 
10         
 50 1049 506 0.482 10.12 26.0 19.567 
16         
 50 1049 527 0.502 10.54 26.0 24.529 
30         
 50 1050 602 0.573 12.04 26.0 42.116 
50         
 50 1047 710 0.678 14.20 31.5 68.093
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 565 0.538 11.30 26.0 33.382
Mitomycin-C 
 0.005     
 10 210 320 1.524 32.00 26.0 277.718
Trend: 9.051        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/18/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 446 0.424 8.92 26.0 0.000
Test Chemical 4,4'-Thiodianiline 
5         
 50 1050 462 0.440 9.24 26.0 3.686 
16         
 50 1047 545 0.521 10.90 26.0 22.664 
50         
 50 1050 473 0.450 9.46 26.0 6.155 
160         
 50 1048 499 0.476 9.98 26.0 12.204
Positive Control Cyclophosphamide 
 0.1       
 50 1050 625 0.595 12.50 26.0 40.268
Cyclophosphamide 
 0.6       
 10 210 227 1.081 22.70 26.0 154.727
Trend: 1.728        
Probability: 0.042