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Study Information
Study Attribute Value
CEBS Accession Number: 002-01470-0002-0000-6
Chemical Name: 4,4'-Thiodianiline
CASRN: 139-65-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 915540_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 10/02/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 4,4'-Thiodianiline 
50         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
100         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0 
160         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 50 0.250 20.5 29 0.145 13.0 21 0.105 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 32.0 11 0.220 18.0 9 0.180 16.0 0 0.000 0.0
Trend: 0.832 0.000 0.832  
Probability: 0.203 0.000 0.203  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/02/1986    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Test Chemical: 4,4'-Thiodianiline 
50         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
100         
 200 20 0.100 5.5 5 0.025 2.5 5 0.025 2.5 10 0.050 1.0 
160         
 200 42 0.210 12.5 21 0.105 7.0 21 0.105 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 36 0.180 16.0 10 0.050 4.5 26 0.130 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 25 0.500 42.0 7 0.140 12.0 18 0.360 32.0 0 0.000 0.0
Trend: 5.424 4.361 3.782  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 11/13/1986    Harvest Time: 13.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4'-Thiodianiline 
50         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
100         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
160         
 200 15 0.075 5.5 3 0.015 1.5 12 0.060 4.5 0 0.000 0.0 
300         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 34 0.170 16.0 11 0.055 5.0 23 0.115 11.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 17 0.340 30.0 5 0.100 10.0 12 0.240 22.0 0 0.000 0.0
Trend: 2.792 1.748 2.451  
Probability: 0.003 0.040 0.007