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Study Information
Study Attribute Value
CEBS Accession Number: 002-01472-0002-0000-8
Chemical Name: 4,4-Thiobis(6-tert-butyl-m-cresol)
CASRN: 96-69-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 395386_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/19/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4-Thiobis(6-tert-butyl-m-cresol) 
3         
 100 5 0.050 5.0 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 
4         
 100 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 2 0.020 2.0 
5         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
7.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.035     
 100 16 0.160 14.0 4 0.040 4.0 12 0.120 10.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 13 0.520 40.0 7 0.280 28.0 6 0.240 24.0 0 0.000 0.0
Trend: -1.280 -2.236 0.366  
Probability: 0.900 0.987 0.357  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/19/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4-Thiobis(6-tert-butyl-m-cresol) 
7.5       
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
10         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 
12.5       
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
15         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 100 19 0.190 10.0 5 0.050 5.0 4 0.040 4.0 10 0.100 1.0
Cyclophosphamide 
12.5       
 25 18 0.720 40.0 13 0.520 36.0 5 0.200 16.0 0 0.000 0.0
Trend: 0.960 0.582 0.811  
Probability: 0.168 0.280 0.209