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Study Information
Study Attribute Value
CEBS Accession Number: 002-01472-0002-0000-8
Chemical Name: 4,4-Thiobis(6-tert-butyl-m-cresol)
CASRN: 96-69-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 395386_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/19/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 5 0.050 5.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4,4-Thiobis(6-tert-butyl-m-cresol)
3         
100 5 0.050 5.0 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0
4         
100 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 2 0.020 2.0
5         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
7.5       
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.035     
100 16 0.160 14.0 4 0.040 4.0 12 0.120 10.0 0 0.000 0.0
Mitomycin-C
 0.0625    
25 13 0.520 40.0 7 0.280 28.0 6 0.240 24.0 0 0.000 0.0
Trend: -1.280 -2.236 0.366  
Probability: 0.900 0.987 0.357  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/19/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4,4-Thiobis(6-tert-butyl-m-cresol)
7.5       
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
10         
100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
12.5       
100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
15         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
100 19 0.190 10.0 5 0.050 5.0 4 0.040 4.0 10 0.100 1.0
Cyclophosphamide
12.5       
25 18 0.720 40.0 13 0.520 36.0 5 0.200 16.0 0 0.000 0.0
Trend: 0.960 0.582 0.811  
Probability: 0.168 0.280 0.209