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Study Information
Study Attribute Value
CEBS Accession Number: 002-01478-0001-0000-3
Chemical Name: 4-(Chloroacetyl)acetanilide
CASRN: 140-49-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 223043_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 417 0.398 8.34 26.5 0.000
Test Chemical 4-(Chloroacetyl)acetanilide 
 0.16      
 50 1044 527 0.505 10.54 26.5 26.742 
 0.5       
 50 1045 603 0.577 12.06 26.5 44.881 
1.6       
 50 1013 623 0.615 12.46 26.5 54.415 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 610 0.581 12.20 26.5 45.865
Mitomycin-C 
 0.01      
 10 210 398 1.895 39.80 26.5 375.855
Trend: 7.185        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/09/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 449 0.433 8.98 27.0 0.000
Test Chemical 4-(Chloroacetyl)acetanilide 
 0.5       
 50 1024 499 0.487 9.98 27.0 12.655 
1         
 50 1037 517 0.499 10.34 27.0 15.256 
2         
 50 1029 577 0.561 11.54 27.0 29.632 
3         
 31 631 344 0.545 11.10 27.0 26.032 
4         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1026 626 0.610 12.52 27.0 41.052
Mitomycin-C 
 0.005     
 10 206 302 1.466 30.20 27.0 238.915
Trend: 4.221        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/07/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 387 0.369 7.74 26.5 0.000
Test Chemical 4-(Chloroacetyl)acetanilide 
 0.16      
 50 1047 435 0.415 8.70 26.5 12.725 
 0.5       
 50 1047 428 0.409 8.56 26.5 10.911 
1.6       
 50 1050 490 0.467 9.80 26.5 26.615 
5         
 50 1039 541 0.521 10.82 26.5 41.273 
16         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1050 612 0.583 12.24 26.5 58.140
Cyclophosphamide 
 0.6       
 10 210 149 0.710 14.90 26.5 92.506
Trend: 5.503        
Probability: 0.000