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Study Information
Study Attribute Value
CEBS Accession Number: 002-01480-0001-0000-6
Chemical Name: 4-Acetyl pyridine
CASRN: 1122-54-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 897590_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/08/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1043 317 0.304 6.34 26.0 0.000
Test Chemical 4-Acetyl pyridine 
49.9       
 50 1030 414 0.402 8.28 26.0 32.248 
150         
 50 1016 459 0.452 9.18 26.0 48.643 
499         
 50 1023 933 0.912 18.66 26.0 200.076 
1500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1041 479 0.460 9.58 26.0 51.394
Mitomycin-C 
 0.01      
 20 420 290 0.690 14.50 26.0 127.182
Trend: 18.865        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/20/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 474 0.452 9.48 26.5 0.000
Test Chemical 4-Acetyl pyridine 
303         
 50 1045 790 0.756 15.80 26.5 67.145 
404         
 50 1043 923 0.885 18.46 26.5 95.659 
505         
 50 1048 1069 1.020 21.38 26.5 125.527 
758         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0015    
 25 521 989 1.898 39.56 26.5 319.702
Mitomycin-C 
 0.01      
 10 210 828 3.943 82.80 26.5 771.754
Trend: 15.179        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/08/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 482 0.459 9.64 26.0 0.000
Test Chemical 4-Acetyl pyridine 
499         
 50 1050 500 0.476 10.00 26.0 3.636 
1500         
 50 1050 587 0.559 11.74 26.0 21.668 
4990         
 50 1044 678 0.649 13.56 26.0 41.338
Positive Control Cyclophosphamide 
 0.4       
 50 1048 531 0.507 10.62 26.0 10.271
Cyclophosphamide 
2.5       
 10 210 224 1.067 22.40 26.0 132.144
Trend: 6.456        
Probability: 0.000