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Study Information
Study Attribute Value
CEBS Accession Number: 002-01480-0002-0000-7
Chemical Name: 4-Acetyl pyridine
CASRN: 1122-54-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 897590_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 
No Activation  3  Positive 
No Activation  4  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 09/09/1986    Harvest Time: 20.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 11 0.055 5.5 4 0.020 2.0 7 0.035 3.5 0 0.000 0.0
Test Chemical: 4-Acetyl pyridine 
501         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
1000         
 200 18 0.090 8.5 4 0.020 2.0 13 0.065 6.5 1 0.005 1.0 
1500         
 200 35 0.175 15.5 9 0.045 4.5 25 0.125 12.0 1 0.005 1.0 
3010         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 50 88 1.760 56.0 18 0.360 24.0 30 0.600 36.0 40 0.800 4.0
Mitomycin-C 
5         
 10 100 10.000 100.0 0 0.000 0.0 0 0.000 0.0 100 10.000 10.0
Trend: 4.044 1.960 3.760  
Probability: 0.000 0.025 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/17/1986    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 10 0.050 3.0 3 0.015 1.5 7 0.035 2.0 0 0.000 0.0
Test Chemical: 4-Acetyl pyridine 
514         
 200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0 
1540         
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
5140         
 50 85 1.700 56.0 26 0.520 36.0 19 0.380 30.0 40 0.800 4.0
Positive Control: Cyclophosphamide 
50         
 50 32 0.640 28.0 9 0.180 14.0 13 0.260 20.0 10 0.200 1.0
Trend: 8.294 6.692 5.979  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 07/17/1986    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 4-Acetyl pyridine 
308         
 200 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 1 0.005 1.0 
1030         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
3080         
 200 8 0.040 3.5 1 0.005 0.5 7 0.035 3.0 0 0.000 0.0 
5140         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 54 0.270 21.0 28 0.140 12.5 26 0.130 11.0 0 0.000 0.0
Mitomycin-C 
5         
 50 67 1.340 48.0 22 0.440 34.0 14 0.280 20.0 31 0.620 4.0
Trend: 1.551 0.207 2.017  
Probability: 0.060 0.418 0.022  


Trial #:3   Activation: No Activation    Date: 09/18/1986    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 4-Acetyl pyridine 
985         
 200 26 0.130 8.5 2 0.010 1.0 14 0.070 7.0 10 0.050 1.0 
1230         
 200 18 0.090 7.5 4 0.020 2.0 14 0.070 6.0 0 0.000 0.0 
1480         
 200 35 0.175 16.0 11 0.055 5.5 24 0.120 11.5 0 0.000 0.0 
1720         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 50 56 1.120 36.0 14 0.280 22.0 22 0.440 24.0 20 0.400 2.0
Mitomycin-C 
5         
 10 95 9.500 100.0 3 0.300 10.0 2 0.200 10.0 90 9.000 9.0
Trend: 4.775 3.814 3.656  
Probability: 0.000 0.000 0.000  


Trial #:4   Activation: No Activation    Date: 10/28/1986    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 7 0.035 3.0 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0
Test Chemical: 4-Acetyl pyridine 
1500         
 200 15 0.075 5.5 3 0.015 1.5 11 0.055 4.0 1 0.005 1.0 
3000         
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0 
5000         
 100 77 0.770 28.0 20 0.200 13.0 26 0.260 20.0 31 0.310 4.0
Positive Control: Mitomycin-C 
 0.1       
 200 20 0.100 7.5 3 0.015 1.5 16 0.080 6.0 1 0.005 1.0
Mitomycin-C 
5         
 25 107 4.280 88.0 18 0.720 44.0 19 0.760 40.0 70 2.800 7.0
Trend: 5.558 4.065 4.585  
Probability: 0.000 0.000 0.000