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Study Information
Study Attribute Value
CEBS Accession Number: 002-01481-0002-0000-8
Chemical Name: 4-Acetylaminofluorene
CASRN: 28322-02-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 710698_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/09/1987    Harvest Time: 20.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: 4-Acetylaminofluorene 
25         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
500         
 200 6 0.030 2.0 1 0.005 0.5 5 0.025 1.5 0 0.000 0.0 
750         
 200 14 0.070 2.5 3 0.015 1.5 11 0.055 1.5 0 0.000 0.0 
1000         
 200 26 0.130 3.5 3 0.015 1.5 3 0.015 1.5 20 0.100 1.0
Positive Control: Mitomycin-C 
 0.05      
 50 24 0.480 32.0 11 0.220 18.0 13 0.260 18.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 12 0.480 44.0 6 0.240 24.0 6 0.240 24.0 0 0.000 0.0
Trend: 0.382 0.847 -0.223  
Probability: 0.351 0.199 0.588  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/08/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Acetylaminofluorene 
500         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
750         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
1000         
 200 4 0.020 1.5 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 20 0.100 8.5 7 0.035 3.5 13 0.065 6.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 11 0.440 32.0 8 0.320 28.0 3 0.120 12.0 0 0.000 0.0
Trend: 2.250 2.216 1.296  
Probability: 0.012 0.013 0.098