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Study Information
Study Attribute Value
CEBS Accession Number: 002-01481-0007-0000-3
Chemical Name: 4-Acetylaminofluorene
CASRN: 28322-02-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A19956_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/12/84 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.8995
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical 4-Acetylaminofluorene 
500         
 8 1.25 ± 0.37 0.2386
  
1000         
 8 0.50 ± 0.33 0.6731
  
2000         
 8 0.25 ± 0.25 0.8420
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/29/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0006
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 16.75 ± 3.94 0.0000
Test Chemical 4-Acetylaminofluorene 
500         
 8 1.50 ± 0.63 0.2622
  
1000         
 8 0.50 ± 0.33 0.7938
  
2000         
 8 4.00 ± 1.56 0.0033
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/15/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4309
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 35.00 ± 2.20 0.0000
Test Chemical 4-Acetylaminofluorene 
2000         
 8 2.75 ± 0.92 0.3253
  
2500         
 8 2.25 ± 0.59 0.5000
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.70 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed