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Study Information
Study Attribute Value
CEBS Accession Number: 002-01482-0001-0000-8
Chemical Name: 4-Amino-2-nitrophenol
CASRN: 119-34-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 524919_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 03/11/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 408 0.391 8.16 26.0 0.000
Test Chemical 4-Amino-2-nitrophenol 
 0.5       
 50 1050 417 0.397 8.34 26.0 1.622 
1.6       
 50 1050 418 0.398 8.36 26.0 1.866 
5         
 50 1050 466 0.444 9.32 26.0 13.563 
16         
 50 1048 613 0.585 12.26 26.0 49.672 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 577 0.550 11.54 26.0 40.613
Mitomycin-C 
 0.005     
 10 210 285 1.357 28.50 26.0 247.269
Trend: 6.690        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/22/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 419 0.403 8.38 26.0 0.000
Test Chemical 4-Amino-2-nitrophenol 
5         
 50 1047 455 0.435 9.10 26.0 7.762 
16         
 50 1047 593 0.566 11.86 26.0 40.446 
30         
 50 1051 726 0.691 14.52 31.0 71.291 
50         
 50 1043 834 0.800 16.68 31.0 98.282
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 504 0.481 10.08 26.0 19.253
Mitomycin-C 
 0.005     
 10 210 254 1.210 25.40 26.0 199.927
Trend: 13.883        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/11/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 477 0.455 9.54 26.0 0.000
Test Chemical 4-Amino-2-nitrophenol 
16         
 50 1051 475 0.452 9.50 26.0 -0.609 
50         
 50 1050 513 0.489 10.26 26.0 7.445 
160         
 50 1050 547 0.521 10.94 26.0 14.566 
500         
 50 1050 664 0.632 13.28 26.0 39.071
Positive Control Cyclophosphamide 
 0.15      
 50 1050 629 0.599 12.58 26.0 31.740
Cyclophosphamide 
 0.6       
 10 210 222 1.057 22.20 26.0 132.483
Trend: 6.089        
Probability: 0.000