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Study Information
Study Attribute Value
CEBS Accession Number: 002-01482-0002-0000-9
Chemical Name: 4-Amino-2-nitrophenol
CASRN: 119-34-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 524919_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 06/11/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 4-Amino-2-nitrophenol 
50         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
100         
 200 13 0.065 5.5 2 0.010 1.0 11 0.055 4.5 0 0.000 0.0 
160         
 200 9 0.045 4.5 4 0.020 2.0 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 38 0.190 17.0 12 0.060 6.0 26 0.130 12.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 22 0.440 36.0 11 0.220 16.0 11 0.220 22.0 0 0.000 0.0
Trend: 2.594 2.176 1.690  
Probability: 0.005 0.015 0.045  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/11/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 4-Amino-2-nitrophenol 
160         
 200 16 0.080 5.5 6 0.030 1.5 10 0.050 4.5 0 0.000 0.0 
300         
 200 35 0.175 13.0 10 0.050 3.0 25 0.125 11.0 0 0.000 0.0 
500         
 131 28 0.214 16.0 14 0.107 9.2 14 0.107 9.9 0 0.000 0.0 
1000         
 200 48 0.240 16.5 19 0.095 8.0 29 0.145 12.5 0 0.000 0.0 
1600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 47 0.235 21.0 13 0.065 6.5 34 0.170 15.5 0 0.000 0.0
Cyclophosphamide 
5         
 50 17 0.340 30.0 4 0.080 8.0 13 0.260 24.0 0 0.000 0.0
Trend: 5.970 4.758 4.953  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/23/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 4-Amino-2-nitrophenol 
300         
 200 41 0.205 11.5 11 0.055 4.0 20 0.100 8.5 10 0.050 1.0 
500         
 200 24 0.120 8.5 10 0.050 3.0 14 0.070 6.5 0 0.000 0.0 
1000         
 200 37 0.185 12.5 14 0.070 5.5 23 0.115 9.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 39 0.195 18.5 7 0.035 3.5 32 0.160 16.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 20 0.400 30.0 4 0.080 6.0 16 0.320 28.0 0 0.000 0.0
Trend: 3.641 2.863 3.079  
Probability: 0.000 0.002 0.001