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Study Information
Study Attribute Value
CEBS Accession Number: 002-01485-0001-0000-1
Chemical Name: 4-Biphenylamine
CASRN: 92-67-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 345000_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
No Activation  3  Test Failure 
No Activation  4  Test Failure 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/27/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 467 0.446 9.34 26.0 0.000
Negative (Not Specified) 
0         
 50 1041 438 0.421 8.76 26.0 -5.579
Test Chemical 4-Biphenylamine 
 0.5       
 50 1040 446 0.429 8.92 26.0 -3.762 
1.6       
 50 1032 475 0.460 9.50 26.0 3.290 
5         
 50 1034 548 0.530 10.96 26.0 18.934 
16         
 50 1050 605 0.576 12.10 26.0 29.304 
50         
 0 0 0 0.000 0.00 26.0 N/A 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1044 2229 2.135 44.58 26.0 379.131
Trend: 5.299        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/23/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1020 407 0.399 8.14 26.0 0.000
Negative (Not Specified) 
0         
 50 1019 370 0.363 7.40 26.0 -9.002
Test Chemical 4-Biphenylamine 
10         
 50 1029 486 0.472 9.72 26.0 18.366 
20         
 50 1009 509 0.504 10.18 26.0 26.425 
30         
 50 1012 658 0.650 13.16 26.0 62.949 
50         
 0 0 0 0.000 0.00 26.0 N/A 
75         
 0 0 0 0.000 0.00 26.0 N/A 
100         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1020 1947 1.909 38.94 26.0 378.378
Trend: 7.646        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 09/23/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1020 407 0.399 8.14 26.0 0.000
Negative (Not Specified) 
0         
 50 1019 370 0.363 7.40 26.0 -9.002
Test Chemical 4-Biphenylamine 
25         
 50 1011 679 0.672 13.58 30.0 68.316 
50         
 0 0 0 0.000 0.00 30.0 N/A 
100         
 0 0 0 0.000 0.00 30.0 N/A 
150         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1020 1947 1.909 38.94 26.0 378.378
Trend: 8.400        
Probability: 0.000        

Trial #: 4    Activation: No Activation    Date: 10/08/1982    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 0 0 0 0.000 0.00 35.0 N/A
Dimethyl Sulfoxide 
0         
 0 0 0 0.000 0.00 35.0 N/A
Test Chemical 4-Biphenylamine 
30         
 50 1039 622 0.599 12.44 35.0 0.000 
40         
 50 1034 734 0.710 14.68 35.0 0.000 
50         
 50 1036 797 0.769 15.94 35.0 0.000 
75         
 50 1037 786 0.758 15.72 35.0 0.000 
100         
 0 0 0 0.000 0.00 35.0 N/A
Positive Control Mitomycin-C 
 0.01      
 0 0 0 0.000 0.00 35.0 N/A
Trend: 4.346        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/27/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 463 0.443 9.26 26.0 1.049
Dimethyl Sulfoxide 
0         
 50 1040 456 0.438 9.12 26.0 0.000
Test Chemical 4-Biphenylamine 
 0.5       
 50 1044 466 0.446 9.32 26.0 1.801 
1.6       
 50 1034 469 0.454 9.38 26.0 3.448 
5         
 50 1043 519 0.498 10.38 26.0 13.488 
16         
 50 1046 650 0.621 13.00 26.0 41.726 
50         
 50 1041 788 0.757 15.76 26.0 72.641 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1039 1683 1.620 33.66 26.0 269.434
Trend: 11.382        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/23/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 400 0.389 8.00 26.0 0.000
Negative (Not Specified) 
0         
 50 1031 360 0.349 7.20 26.0 -10.349
Test Chemical 4-Biphenylamine 
10         
 50 1026 466 0.454 9.32 26.0 16.614 
20         
 50 1016 478 0.470 9.56 26.0 20.794 
30         
 50 1027 626 0.610 12.52 26.0 56.500 
40         
 50 1035 610 0.589 12.20 26.0 51.321 
50         
 50 1024 626 0.611 12.52 26.0 56.958 
75         
 50 1018 692 0.680 13.84 26.0 74.529 
100         
 50 1023 669 0.654 13.38 26.0 67.904
Positive Control Cyclophosphamide 
1.5       
 50 1026 1702 1.659 34.04 26.0 325.915
Trend: 11.406        
Probability: 0.000