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Study Information
Study Attribute Value
CEBS Accession Number: 002-01485-0002-0000-2
Chemical Name: 4-Biphenylamine
CASRN: 92-67-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 345000_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/01/1982    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Biphenylamine 
16         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
25         
 100 6 0.060 6.0 6 0.060 6.0 0 0.000 0.0 0 0.000 0.0 
50         
 100 6 0.060 6.0 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 
100         
 100 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0 3 0.030 3.0
Positive Control: Mitomycin-C 
 0.5       
 100 42 0.420 30.0 21 0.210 19.0 11 0.110 8.0 10 0.100 10.0
Trend: 1.892 0.625 0.689  
Probability: 0.029 0.266 0.246  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/23/1982    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Biphenylamine 
25         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
50         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
75         
 100 6 0.060 6.0 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 
100         
 100 10 0.100 9.0 2 0.020 2.0 7 0.070 7.0 1 0.010 1.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 87 0.870 54.0 20 0.200 19.0 44 0.440 34.0 23 0.230 14.0
Trend: 2.912 0.921 2.759  
Probability: 0.002 0.178 0.003  


Trial #:2   Activation: No Activation    Date: 09/23/1982    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Biphenylamine 
10         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
25         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
50         
 100 7 0.070 6.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 6 0.060 6.0 2 0.020 2.0 3 0.030 3.0 1 0.010 1.0 
75         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
100         
 100 8 0.080 8.0 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 
100         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.5       
 100 43 0.430 27.0 22 0.220 18.0 15 0.150 10.0 6 0.060 6.0
Trend: 2.074 1.456 1.230  
Probability: 0.019 0.073 0.109