Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01485-0002-0000-2
Chemical Name: 4-Biphenylamine
CASRN: 92-67-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 345000_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/01/1982    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Biphenylamine 
16         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
25         
 100 6 0.060 6.0 6 0.060 6.0 0 0.000 0.0 0 0.000 0.0 
50         
 100 6 0.060 6.0 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 
100         
 100 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0 3 0.030 3.0
Positive Control: Mitomycin-C 
 0.5       
 100 42 0.420 30.0 21 0.210 19.0 11 0.110 8.0 10 0.100 10.0
Trend: 1.892 0.625 0.689  
Probability: 0.029 0.266 0.246  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/23/1982    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Biphenylamine 
25         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
50         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
75         
 100 6 0.060 6.0 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 
100         
 100 10 0.100 9.0 2 0.020 2.0 7 0.070 7.0 1 0.010 1.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 87 0.870 54.0 20 0.200 19.0 44 0.440 34.0 23 0.230 14.0
Trend: 2.912 0.921 2.759  
Probability: 0.002 0.178 0.003  


Trial #:2   Activation: No Activation    Date: 09/23/1982    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Biphenylamine 
10         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
25         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
50         
 100 7 0.070 6.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 
50         
 100 6 0.060 6.0 2 0.020 2.0 3 0.030 3.0 1 0.010 1.0 
75         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
100         
 100 8 0.080 8.0 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 
100         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.5       
 100 43 0.430 27.0 22 0.220 18.0 15 0.150 10.0 6 0.060 6.0
Trend: 2.074 1.456 1.230  
Probability: 0.019 0.073 0.109