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Study Information
Study Attribute Value
CEBS Accession Number: 002-01488-0001-0000-4
Chemical Name: 4-Chloro-2-nitroaniline
CASRN: 89-63-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 908592_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 03/04/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1030 432 0.419 8.64 25.3 0.000
Test Chemical 4-Chloro-2-nitroaniline 
18         
 50 1028 512 0.498 10.24 32.0 18.749 
20         
 50 1020 520 0.510 10.40 32.0 21.550 
25         
 50 1035 529 0.511 10.58 32.0 21.862
Positive Control Mitomycin-C 
 0.01      
 3 61 560 9.180 186.67 32.0 2088.828
Trend: 2.846        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/04/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 446 0.426 8.92 25.2 0.000
Test Chemical 4-Chloro-2-nitroaniline 
252         
 50 1037 514 0.496 10.28 25.2 16.469 
302         
 50 1044 563 0.539 11.26 25.2 26.717 
351         
 50 1030 526 0.511 10.52 25.2 19.998
Positive Control Cyclophosphamide 
20         
 25 515 596 1.157 23.84 25.2 171.935
Trend: 3.142        
Probability: 0.001