Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01488-0002-0000-5 |
Chemical Name: | 4-Chloro-2-nitroaniline |
CASRN: | 89-63-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 908592_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 2.0 | 2 | 0.020 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 4-Chloro-2-nitroaniline | 151 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
200 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
252 | 100 | 10 | 0.100 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 10 | 0.100 | 1.0 | ||
302 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 | 50 | 48 | 0.960 | 40.0 | 20 | 0.400 | 34.0 | 18 | 0.360 | 24.0 | 10 | 0.200 | 1.0 |
Trend: | -1.046 | -1.346 | -1.324 | ||||||||||||
Probability: | 0.852 | 0.911 | 0.907 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 4.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 4-Chloro-2-nitroaniline | 252 | 100 | 8 | 0.080 | 6.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 4.0 | 1 | 0.010 | 1.0 |
302 | 50 | 40 | 0.800 | 42.0 | 36 | 0.720 | 42.0 | 4 | 0.080 | 6.0 | 0 | 0.000 | 0.0 | ||
351 | 50 | 87 | 1.740 | 56.0 | 36 | 0.720 | 40.0 | 41 | 0.820 | 42.0 | 10 | 0.200 | 1.0 | ||
Positive Control: | Cyclophosphamide | 15 | 50 | 12 | 0.240 | 22.0 | 5 | 0.100 | 8.0 | 7 | 0.140 | 10.0 | 0 | 0.000 | 0.0 |
Trend: | 8.637 | 7.899 | 6.435 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |