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Study Information
Study Attribute Value
CEBS Accession Number: 002-01495-0001-0000-2
Chemical Name: 4-Chloro-o-toluidine hydrochloride
CASRN: 3165-93-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333979_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/07/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1029 418 0.406 8.36 26.3 0.000
Test Chemical 4-Chloro-o-toluidine hydrochloride 
50         
 50 1035 1461 1.412 29.22 26.3 247.495 
100         
 50 1055 1637 1.552 32.74 26.3 281.975 
200         
 50 1043 1523 1.460 30.46 33.3 259.463
Positive Control Mitomycin-C 
 0.01      
 25 523 1256 2.402 50.24 26.3 491.190
Trend: 21.558        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/07/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1039 405 0.390 8.10 26.3 0.000
Test Chemical 4-Chloro-o-toluidine hydrochloride 
25         
 50 1040 483 0.464 9.66 26.3 19.145 
50         
 50 1038 526 0.507 10.52 26.3 30.002 
100         
 50 1042 707 0.679 14.14 33.3 74.065
Positive Control Cyclophosphamide 
1.5       
 25 520 579 1.113 23.16 26.3 185.651
Trend: 9.178        
Probability: 0.000