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Study Information
Study Attribute Value
CEBS Accession Number: 002-01495-0002-0000-3
Chemical Name: 4-Chloro-o-toluidine hydrochloride
CASRN: 3165-93-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 333979_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 07/07/1982    Harvest Time: 19.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Chloro-o-toluidine hydrochloride 
125         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
150         
 100 3 0.030 2.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
175         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 50 21 0.420 26.0 13 0.260 18.0 8 0.160 12.0 0 0.000 0.0
Trend: -0.408 -0.203 0.500  
Probability: 0.658 0.580 0.309  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/07/1982    Harvest Time: 19.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Water 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Chloro-o-toluidine hydrochloride 
300         
 100 8 0.080 7.0 5 0.050 5.0 3 0.030 2.0 0 0.000 0.0 
350         
 100 8 0.080 5.0 7 0.070 4.0 1 0.010 1.0 0 0.000 0.0 
400         
 100 140 1.400 37.0 41 0.410 23.0 29 0.290 17.0 70 0.700 7.0
Positive Control: Cyclophosphamide 
10         
 50 21 0.420 32.0 16 0.320 30.0 5 0.100 8.0 0 0.000 0.0
Trend: 6.780 4.883 5.033  
Probability: 0.000 0.000 0.000