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Study Information
Study Attribute Value
CEBS Accession Number: 002-01498-0001-0000-5
Chemical Name: 4-Chloronitrobenzene
CASRN: 100-00-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 565306_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/18/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 412 0.395 8.24 25.7 0.000
Test Chemical 4-Chloronitrobenzene 
100         
 50 1034 394 0.381 7.88 25.7 -3.629 
150         
 50 1034 481 0.465 9.62 30.4 17.651 
200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1037 1689 1.629 33.78 25.7 311.928
Trend: 2.555        
Probability: 0.005        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/18/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 259 0.249 5.18 25.5 10.425
Dimethyl Sulfoxide 
0         
 50 1042 235 0.226 4.70 25.5 0.000
Test Chemical 4-Chloronitrobenzene 
250         
 50 1029 367 0.357 7.34 25.5 58.143 
400         
 50 1030 359 0.349 7.18 25.5 54.546 
500         
 50 1027 427 0.416 8.54 25.5 84.356
Positive Control Cyclophosphamide 
2         
 50 1044 1349 1.292 26.98 25.5 472.943
Trend: 6.796        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/07/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 318 0.306 6.36 25.5 0.000
Test Chemical 4-Chloronitrobenzene 
300         
 50 1038 421 0.406 8.42 25.5 32.645 
400         
 50 1040 409 0.393 8.18 25.5 28.616 
500         
 50 1027 547 0.533 10.94 28.5 74.190
Positive Control Cyclophosphamide 
1.5       
 50 1041 1342 1.289 26.84 25.5 321.607
Trend: 7.357        
Probability: 0.000