Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01500-0003-0000-1 |
Chemical Name: | 4-Dimethylaminoazobenzene |
CASRN: | 60-11-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 258568 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 77 | 99 | 130 | 56 | 48 |
80 | 112 | 109 | 46 | ||||
76# | 91 | 121 | 53 | ||||
82# | 98 | 93 | 38 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 20 | 84 | 92 | 93 | 37 | 38 |
75 | 83 | 89 | 39 | ||||
25 | 85 | 97 | 165 | 65 | 58 | ||
88 | 108 | 134 | 51 | ||||
31 | 76 | 84 | 97 | 42 | 65 | ||
64 | 69 | 170 | 88 | ||||
38 | 66 | 76 | 148 | 75 | 90* | ||
82 | 87 | 256 | 104 | ||||
48 | 73 | 84 | 115 | 52 | 72 | ||
62 | 61 | 169 | 91 | ||||
60 | 73 | 84 | 100 | 46 | 57 | ||
63 | 73 | 129 | 68 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 42 | 39 | 758 | 597 | 569* |
37 | 36 | 713 | 642 | ||||
53 | 52 | 747 | 468 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 62 | 91 | 57 | 31 | 28 |
68 | 93 | 53 | 26 | ||||
64 | 90 | 66 | 35 | ||||
92 | 125 | 61 | 22 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 47 | 58 | 73 | 65 | 38 | 41 |
65 | 81 | 74 | 38 | ||||
48 | 66 | 69 | 48 | ||||
52 | 58# | 74 | 30 | 17 | 29 | ||
67 | 87 | 68 | 34 | ||||
68 | 85 | 73 | 36 | ||||
58 | 64 | 81 | 48 | 25 | 28 | ||
69 | 86 | 69 | 34 | ||||
67 | 80 | 48 | 24 | ||||
65 | 68 | 81 | 67 | 33 | 29 | ||
61 | 71 | 50 | 27 | ||||
59 | 78 | 48 | 27 | ||||
72 | 64 | 71 | 39 | 20 | 22 | ||
62 | 75 | 49 | 26 | ||||
70 | 79 | 43 | 20 | ||||
80 | 70 | 79 | 65 | 31 | 27 | ||
67 | 70 | 42 | 21 | ||||
58 | 65 | 50 | 29 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 48 | 53 | 660 | 463 | 452* |
39 | 39 | 601 | 514 | ||||
47 | 53 | 535 | 378 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 87 | 116 | 144 | 55 | 41 |
78 | 98 | 84 | 36 | ||||
74 | 89 | 91 | 41 | ||||
72 | 97 | 73 | 34 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 8 | 75 | 98 | 98 | 44 | 51 |
74 | 106 | 130 | 58 | ||||
10 | 70 | 86 | 147 | 70 | 66* | ||
74 | 88 | 136 | 62 | ||||
13 | 79 | 81 | 149 | 63 | 64 | ||
80 | 84 | 155 | 65 | ||||
16 | 66 | 40 | 178 | 89 | 83* | ||
64 | 39 | 147 | 77 | ||||
20 | 58 | 18 | 120 | 69 | 95* | ||
44 | 15 | 159 | 120 | ||||
25 | 34 | 6 | 131 | 129 | 132* | ||
33 | 6 | 134 | 135 | ||||
Positive Control | 3-Methylcholanthrene | 5 | 61 | 76 | 361 | 197 | 215* |
61 | 73 | 365 | 198 | ||||
60 | 68 | 445 | 249 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 72 | 104 | 70 | 32 | 35 |
56 | 89 | 71 | 43 | ||||
85 | 107 | 77 | 30 | ||||
124r | 149 | 103 | 28 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 9 | 67 | 84 | 86 | 43 | 52 |
67 | 88 | 121 | 61 | ||||
11 | 79 | 85 | 63 | 27 | 27 | ||
76 | 81 | 61 | 27 | ||||
14 | 69 | 50 | 79 | 38 | 51 | ||
50 | 43 | 95 | 63 | ||||
18 | 61# | 17 | 25.5 | 14 | 10 | ||
60 | 24 | 12 | 7 | ||||
22 | 22 | 2 | 9 | 14 | |||
28 | |||||||
Positive Control | 3-Methylcholanthrene | 6 | 49 | 35 | 331 | 225 | 244* |
40 | 32 | 122 | 103 | ||||
38 | 29 | 455 | 404 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 94 | 91 | 128 | 46 | 38 |
118 | 114 | 137 | 39 | ||||
108 | 105 | 95 | 29 | ||||
98 | 89 | 115 | 39 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 16 | 83 | 36 | 158 | 63 | 60* |
77 | 30 | 182 | 79 | ||||
100# | 42 | 111 | 37 | ||||
18 | 72 | 23 | 131 | 61 | 69* | ||
76 | 22 | 175 | 77 | ||||
84 | 31 | 173 | 69 | ||||
20 | 73 | 18 | 164 | 75 | 94* | ||
62 | 17 | 209 | 112 | ||||
22 | 79 | 14 | 158 | 67 | 66* | ||
86 | 14 | 204 | 79 | ||||
92 | 20 | 147 | 53 | ||||
24 | 65 | 7 | 140 | 71 | 85* | ||
64 | 8 | 195 | 102 | ||||
71 | 9 | 173 | 81 | ||||
27 | 40 | 3 | 124 | 102 | 120* | ||
53 | 4 | 224 | 141 | ||||
45 | 3 | 157 | 117 | ||||
30 | |||||||
Positive Control | 3-Methylcholanthrene | 5 | 59 | 39 | 585 | 331 | 282* |
59 | 41 | 504 | 286 | ||||
76 | 62 | 526 | 231 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination