Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01500-0004-0000-2 |
Chemical Name: | 4-Dimethylaminoazobenzene |
CASRN: | 60-11-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 451770 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 89 | 99 | 72 | 27 | 30 |
98 | 90 | 109 | 37 | ||||
97 | 108 | 92 | 32 | ||||
108 | 104 | 82 | 25 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 1.56 | 76 | 67 | 51 | 22 | 24 |
93 | 78 | 71 | 25 | ||||
3.13 | 100 | 94 | 89 | 30 | 27 | ||
97 | 97 | 69 | 24 | ||||
6.25 | 102 | 89 | 97 | 32 | 27 | ||
75 | 76 | 50 | 22 | ||||
12.5 | 87 | 85 | 110 | 42 | 33 | ||
84 | 69 | 58 | 23 | ||||
25 | 94 | 71 | 80 | 28 | 34 | ||
89 | 74 | 105 | 40 | ||||
50 | 91 | 60 | 88 | 32 | 37 | ||
63 | 72 | 79 | 42 | ||||
Positive Control | Ethyl Methane Sulfonate | 500 | 31 | 16 | 765 | 827 | 860* |
32 | 12 | 857 | 893 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 86 | 93 | 78 | 30 | 35 |
85 | 130 | 54 | 21 | ||||
55 | 82 | 88 | 53 | ||||
78 | 95 | 85 | 37 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 10 | 106 | 250 | 46 | 14 | 29 |
68 | 113 | 86 | 42 | ||||
91 | 116 | 83 | 30 | ||||
20 | 68 | 68 | 76 | 38 | 38 | ||
59 | 65 | 86 | 48 | ||||
107 | 130 | 88 | 27 | ||||
30 | 94# | 59 | 69 | 24 | 29 | ||
98 | 73 | 86 | 29 | ||||
55 | 41 | 55 | 34 | ||||
40 | 59 | 47 | 94 | 53 | 46 | ||
70 | 50 | 86 | 41 | ||||
63 | 52 | 82 | 43 | ||||
50 | 53 | 43 | 108 | 68 | 54* | ||
62 | 35 | 94 | 51 | ||||
63 | 52 | 82 | 44 | ||||
60 | 67# | 25 | 72 | 36 | 36 | ||
94 | 53 | 115 | 41 | ||||
60 | 23 | 55 | 30 | ||||
Positive Control | Ethyl Methane Sulfonate | 250 | 6r | 1 | 106 | 642 | 490* |
13# | 6 | 225 | 570 | ||||
22 | 13 | 265 | 411 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 63 | 90 | 44 | 23 | 26 |
69 | 110 | 60 | 29 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 20 | 67# | 80 | 49 | 25 | 21 |
69 | 104 | 36 | 17 | ||||
30 | 72 | 79 | 69 | 32 | 30 | ||
59 | 67 | 66 | 37 | ||||
59# | 71 | 37.5 | 21 | ||||
40 | 66 | 79 | 45 | 23 | 29 | ||
62 | 78 | 56 | 30 | ||||
59# | 74 | 60 | 34 | ||||
50 | 52 | 60 | 48 | 31 | 27 | ||
66 | 78 | 38 | 19 | ||||
66 | 86 | 59 | 30 | ||||
60 | 56# | 63 | 57 | 34 | 26 | ||
53 | 62 | 38 | 24 | ||||
63 | 71 | 38 | 20 | ||||
80 | 55# | 59 | 54 | 33 | 31 | ||
57 | 45 | 51 | 30 | ||||
Positive Control | Ethyl Methane Sulfonate | 250 | 44 | 48 | 690 | 521 | 568* |
42 | 33 | 768 | 614 | ||||
46 | 48 | 789 | 570 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 74 | 94 | 115 | 52 | 44 |
100 | 99 | 137 | 46 | ||||
101 | 92 | 133 | 44 | ||||
104 | 115 | 106 | 34 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 0.39 | 88 | 99 | 139 | 53 | 50 |
87 | 105 | 121 | 46 | ||||
0.78 | 103 | 89 | 187 | 60 | 62 | ||
78# | 87 | 150 | 64 | ||||
1.56 | 64 | 68 | 138 | 72 | 64 | ||
85 | 87 | 144 | 57 | ||||
3.13 | 104 | 66 | 177 | 57 | 65 | ||
91 | 55 | 201 | 74 | ||||
6.25 | 71 | 18 | 235 | 110 | 91* | ||
102 | 27 | 219 | 72 | ||||
12.5 | 99 | 12 | 233 | 79 | 122* | ||
56 | 4 | 279 | 165 | ||||
25 | |||||||
Positive Control | 3-Methylcholanthrene | 5 | 26 | 4 | 315 | 412 | 380* |
30 | 4 | 280 | 309 | ||||
25 | 5 | 315 | 420 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 98 | 107 | 67 | 23 | 20 |
85 | 98 | 60 | 23 | ||||
97 | 90 | 50 | 17 | ||||
86 | 106 | 47 | 18 | ||||
Test Chemical | 4-Dimethylaminoazobenzene | 1.56 | 78# | 58 | 55.5 | 24 | 26 |
61 | 55 | 53 | 29 | ||||
86 | 71 | 64 | 25 | ||||
3.13 | 65 | 43 | 70 | 36 | 28 | ||
73 | 51 | 46 | 21 | ||||
6.25 | 69 | 19 | 96 | 46 | 45* | ||
62 | 17 | 82 | 44 | ||||
10 | 68# | 11 | 118 | 58 | 62* | ||
68 | 11 | 156 | 76 | ||||
73 | 18 | 110 | 50 | ||||
12.5 | 85 | 9 | 233 | 92 | 89* | ||
78 | 11 | 175 | 75 | ||||
48# | 7 | 145.5 | 101 | ||||
15 | 72 | 8 | 179 | 82 | 81* | ||
67 | 7 | 161 | 80 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 72 | 61 | 376 | 175 | 168* |
85 | 62 | 398 | 157 | ||||
89 | 53 | 459 | 172 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination