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Study Information
Study Attribute Value
CEBS Accession Number: 002-01502-0001-0000-1
Chemical Name: 4-Hexylresorcinol
CASRN: 136-77-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 813308_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/23/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 428 0.408 8.56 26.0 0.000
Test Chemical 4-Hexylresorcinol 
1.6       
 50 1048 401 0.383 8.02 26.0 -6.219 
5         
 50 1048 429 0.409 8.58 26.0 0.329 
16         
 50 1047 390 0.372 7.80 26.0 -8.704
Positive Control Mitomycin-C 
 0.005     
 50 1048 687 0.656 13.74 26.0 60.667
Trend: -0.926        
Probability: 0.823        

Trial #: 2    Activation: No Activation    Date: 05/05/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 399 0.380 7.98 26.0 0.000
Test Chemical 4-Hexylresorcinol 
16         
 50 1045 453 0.433 9.06 26.0 13.968 
18         
 50 1030 488 0.474 9.76 26.0 24.562 
20         
 50 1048 508 0.485 10.16 26.0 27.440
Positive Control Mitomycin-C 
 0.005     
 25 524 735 1.403 29.40 26.0 268.773
Trend: 3.855        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/23/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 448 0.428 8.96 26.0 0.000
Test Chemical 4-Hexylresorcinol 
5         
 50 1046 428 0.409 8.56 26.0 -4.464 
16         
 50 1045 466 0.446 9.32 26.0 4.117 
50         
 50 1049 488 0.465 9.76 26.0 8.617
Positive Control Cyclophosphamide 
1         
 50 1049 912 0.869 18.24 26.0 102.989
Trend: 1.615        
Probability: 0.053