Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01502-0011-0000-2
Chemical Name: 4-Hexylresorcinol
CASRN: 136-77-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 356349
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 53 74 84 53 44
    80 108 96 40
    44r 63 48 37
    75 117 87 39
Test Chemical 4-Hexylresorcinol 
1.25      
 76 86 56 25 26
    71 128 45 21
    57 92 53 31
  
2.5       
 57 70 69 40 30
    82 95 66 27
    95 129 66 23
  
5         
 65 105 73 38 30
    69 124 47 23
  
10         
 78 104 44 19 27
    57 82 53 31
    65 117 60 31
  
15         
 71# 26 76 36 36
    92 51 72 26
    64 33 91 47
  
20         
 81 105 64 27
   
   
  
30         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 91 73 520 191 236*
    54 86 365 227
    50 79 436 289

Nonactivation Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 105 158 118 37 41
    72# 81 78 36
    75 87 96 43
    74 73 102 46
Test Chemical 4-Hexylresorcinol 
2.5       
 90 132 87 32 29
    100 113 75 25
    97 115 87 30
  
5         
 88 121 65 25 33
    70 138 77 37
    105 133 124 39
  
7.5       
 90 126 90 33 32
    80 117 71 30
  
10         
 82 139 91 37 40
    91 116 129 47
    90# 103 99 37
  
15         
 94 67 94 34 37
    87 110 80 31
    83 70 119 48
  
20         
 81 48 107 44 57
   
    79 14 165 70
  
25         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 76 66 626 275 288*
    57 52 557 324
    82# 78 657 266

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 105 89 277 88 92
    106 102 273 86
    97 110 256 88
    95 99 306 107
Test Chemical 4-Hexylresorcinol 
2.5       
 70 59 156 74 78
    63 67 144 76
    51# 62 128 83
  
5         
 56 49 273 162 109
    66 47 156 79
    70 48 185 88
  
10         
 82 38 459 186 161*
    82 31 412 169
    69 30 263 128
  
15         
 67 47 314 155 149*
    73 34 297 137
    73 28 334 154
  
20         
 96 21 398 138 129
    74 25 315 141
    102 31 327 107
  
30         
 74 20 247 112 151*
    95 17 561 196
    83 18 363 146
Positive Control 3-Methylcholanthrene 
2.5       
 105 103 538 171 172*
    100 108 448 150
    95 76 557 196

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 79 103 186 78 91
    93 102 279 101
    112 84 325 96
    104 111 276 88
Test Chemical 4-Hexylresorcinol 
2.5       
 74 82 199 90 86
    77 77 206 89
    64 67 149 78
  
5         
 74 61 336 152 145*
    89 73 336 126
    92 83 433 156
  
10         
 74 54 297 135 147*
    72# 48 300 139
    72 50 360 167
  
15         
 87 32 447 171 145*
    84 47 313 124
    104 37 435 139
  
20         
 74 40 517 232 187*
    76 13 440 193
    92 34 373 135
  
30         
 63 6 557 294 201*
    94 14 376 133
    56 9 295 176
  
40         
   
   
Positive Control 3-Methylcholanthrene 
2.5       
 86 102 410 159 225*
    95 108 499 176
    71 33 725 340

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination