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Study Information
Study Attribute Value
CEBS Accession Number: 002-01516-0002-0000-7
Chemical Name: 4-Nitroanthranilic acid
CASRN: 619-17-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 235278_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/09/1984    Harvest Time: 22 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4-Nitroanthranilic acid 
3000         
 67 3 0.045 3.0 0 0.000 0.0 3 0.045 3.0 0 0.000 0.0 
4000         
 24 17 0.708 13.0 17 0.708 13.0 0 0.000 0.0 0 0.000 0.0 
5000         
 46 11 0.239 11.0 9 0.196 9.0 2 0.043 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 33 0.330 27.0 22 0.220 20.0 11 0.110 11.0 0 0.000 0.0
Mitomycin-C 
1         
 50 32 0.640 50.0 27 0.540 42.0 5 0.100 10.0 0 0.000 0.0
Trend: 3.128 3.678 0.232  
Probability: 0.001 0.000 0.408  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/08/1984    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4-Nitroanthranilic acid 
160         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
300         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
1000         
 100 2 0.020 1.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
1600         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 45 0.450 38.0 32 0.320 27.0 13 0.130 13.0 0 0.000 0.0
Trend: 0.336 0.817 0.188  
Probability: 0.368 0.207 0.425  


Trial #:2   Activation: No Activation    Date: 01/31/1985    Harvest Time: 13.3 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 4-Nitroanthranilic acid 
1600         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 
2200         
 100 6 0.060 6.0 4 0.040 4.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 26 0.260 23.0 13 0.130 13.0 12 0.120 11.0 1 0.010 1.0
Mitomycin-C 
 0.25      
 50 21 0.420 28.0 12 0.240 16.0 9 0.180 18.0 0 0.000 0.0
Trend: 1.819 1.014 2.007  
Probability: 0.034 0.155 0.022  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/31/1985    Harvest Time: 11.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 4-Nitroanthranilic acid 
2200         
 100 13 0.130 9.0 7 0.070 6.0 6 0.060 6.0 0 0.000 0.0 
2800         
 100 18 0.180 15.0 6 0.060 6.0 12 0.120 11.0 0 0.000 0.0 
3400         
 100 50 0.500 35.0 18 0.180 14.0 32 0.320 26.0 1 0.010 1.0 
4000         
 100 21 0.210 11.0 9 0.090 5.0 11 0.110 7.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
15         
 100 41 0.410 32.0 23 0.230 18.0 18 0.180 18.0 0 0.000 0.0
Trend: 3.819 1.620 3.592  
Probability: 0.000 0.053 0.000