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Study Information
Study Attribute Value
CEBS Accession Number: 002-01519-0001-0000-9
Chemical Name: 4-Nitroquinoline-N-oxide
CASRN: 56-57-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 776321_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/04/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 497 0.474 9.94 25.7 0.000
Test Chemical 4-Nitroquinoline-N-oxide 
 0.093     
 50 1042 671 0.644 13.42 25.7 35.787 
 0.31      
 10 210 373 1.776 37.30 25.7 274.537 
 0.93      
 50 1050 1067 1.016 21.34 25.7 114.279 
3.1       
 0 0 0 0.000 0.00 25.7 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1049 741 0.706 14.82 25.7 48.952
Cyclophosphamide 
2         
 5 105 177 1.686 35.40 25.7 255.458
Trend: 16.636        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/26/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 524 227 0.433 9.08 25.5 0.000
Test Chemical 4-Nitroquinoline-N-oxide 
 0.6       
 25 523 378 0.723 15.12 25.5 66.838 
 0.9       
 25 516 464 0.899 18.56 25.5 107.574 
1.2       
 25 520 702 1.350 28.08 25.5 211.630
Positive Control Cyclophosphamide 
 0.4       
 25 525 332 0.632 13.28 25.5 45.977
Cyclophosphamide 
2         
 5 105 170 1.619 34.00 25.5 273.736
Trend: 16.002        
Probability: 0.000