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Study Information
Study Attribute Value
CEBS Accession Number: 002-01519-0002-0000-0
Chemical Name: 4-Nitroquinoline-N-oxide
CASRN: 56-57-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 776321_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/19/1987    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 1.0 1 0.010 1.0 2 0.020 1.0 0 0.000 0.0
Test Chemical: 4-Nitroquinoline-N-oxide 
1.5       
 50 58 1.160 40.0 27 0.540 30.0 21 0.420 26.0 10 0.200 2.0 
2.25      
 50 63 1.260 48.0 27 0.540 36.0 16 0.320 20.0 20 0.400 4.0 
3         
 50 141 2.820 66.0 44 0.880 48.0 27 0.540 30.0 70 1.400 14.0
Positive Control: Cyclophosphamide 
6.25      
 100 22 0.220 17.0 8 0.080 8.0 14 0.140 9.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 19 0.760 56.0 13 0.520 44.0 6 0.240 20.0 0 0.000 0.0
Trend: 8.575 6.853 4.620  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/21/1987    Harvest Time: 20.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: 4-Nitroquinoline-N-oxide 
1.5       
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
2.25      
 200 21 0.105 6.5 8 0.040 2.5 13 0.065 5.5 0 0.000 0.0 
3         
 200 139 0.695 27.0 76 0.380 20.0 53 0.265 15.0 10 0.050 0.5
Positive Control: Cyclophosphamide 
6.25      
 200 16 0.080 6.0 4 0.020 1.5 12 0.060 5.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 12 0.480 36.0 1 0.040 4.0 11 0.440 36.0 0 0.000 0.0
Trend: 8.467 8.118 5.728  
Probability: 0.000 0.000 0.000