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Study Information
Study Attribute Value
CEBS Accession Number: 002-01519-0006-0000-4
Chemical Name: 4-Nitroquinoline-N-oxide
CASRN: 56-57-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 314987_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/15/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 24.75 ± 3.23 0.0000
Test Chemical 4-Nitroquinoline-N-oxide 
15         
 8 4.00 ± 1.46 0.5706
  
30         
 8 12.00 ± 2.62 0.0000
  
60         
 8 37.25 ± 5.53 0.0000
Vehicle Control No Stressor 
 0         
 8 4.25 ± 0.80 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/05/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical 4-Nitroquinoline-N-oxide 
40         
 8 15.75 ± 2.43 0.0000
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed