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Study Information
Study Attribute Value
CEBS Accession Number: 002-01522-0001-0000-3
Chemical Name: 4-Vinyl-1-cyclohexene diepoxide
CASRN: 106-87-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 629851_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 600 0.571 12.00 25.8 0.000
Test Chemical 4-Vinyl-1-cyclohexene diepoxide 
1.12      
 50 1046 808 0.772 16.16 25.8 35.182 
3.73      
 50 1047 1646 1.572 32.92 25.8 175.119 
11.2       
 50 1047 1891 1.806 37.82 25.8 216.070 
37.3       
 0 0 0 0.000 0.00 32.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 711 0.678 14.22 25.8 18.613
Mitomycin-C 
 0.01      
 5 105 238 2.267 47.60 25.8 296.667
Trend: 30.090        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 579 0.551 11.58 25.8 0.000
Test Chemical 4-Vinyl-1-cyclohexene diepoxide 
37.3       
 50 1045 1471 1.408 29.42 25.8 155.517 
112         
 50 1052 1928 1.833 38.56 25.8 232.671 
373         
 5 105 596 5.676 119.20 32.5 930.341
Positive Control Cyclophosphamide 
 0.35      
 50 1049 775 0.739 15.50 25.8 34.107
Cyclophosphamide 
2         
 5 105 168 1.600 33.60 25.8 190.432
Trend: 38.110        
Probability: 0.000