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Study Information
Study Attribute Value
CEBS Accession Number: 002-01522-0002-0000-4
Chemical Name: 4-Vinyl-1-cyclohexene diepoxide
CASRN: 106-87-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 629851_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 02/16/1983    Harvest Time: 22.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 3.0 2 0.020 2.0 4 0.040 1.0 0 0.000 0.0
Test Chemical: 4-Vinyl-1-cyclohexene diepoxide 
37.8       
 100 95 0.950 43.0 13 0.130 13.0 52 0.520 33.0 30 0.300 3.0 
50.3       
 50 151 3.020 82.0 27 0.540 38.0 44 0.880 28.0 80 1.600 16.0 
62.9       
 25 195 7.800 100.0 8 0.320 16.0 14 0.560 36.0 173 6.920 80.0
Positive Control: Mitomycin-C 
 0.05      
 50 49 0.980 50.0 25 0.500 40.0 24 0.480 28.0 0 0.000 0.0
Trend: 11.364 4.732 4.785  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/02/1983    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 11 0.110 8.0 3 0.030 3.0 5 0.050 3.0 3 0.030 3.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 0 0.000 0.0 4 0.040 4.0 1 0.010 1.0
Test Chemical: 4-Vinyl-1-cyclohexene diepoxide 
447         
 100 49 0.490 33.0 19 0.190 17.0 30 0.300 22.0 0 0.000 0.0 
503         
 100 69 0.690 45.0 26 0.260 23.0 43 0.430 31.0 0 0.000 0.0 
548         
 50 46 0.920 60.0 15 0.300 24.0 31 0.620 40.0 0 0.000 0.0 
604         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 32 0.640 38.0 16 0.320 28.0 6 0.120 10.0 10 0.200 2.0
Trend: 7.489 4.717 5.629  
Probability: 0.000 0.000 0.000