Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01522-0008-0000-0
Chemical Name:	4-Vinyl-1-cyclohexene diepoxide
CASRN:	106-87-6
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	496867
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	52	91	83	54	48
			56	102	72	43
			48r	93	87	61
			63#	108	91.5	48
Test Chemical	4-Vinyl-1-cyclohexene diepoxide	25	45	53	247	184	157*
			48#	68	184.5	129	157*
		50	30	49	305	335	273*
			36#	36	229.5	211	273*
		100	13	8	414	1075	895*
			20	21	418	715	895*
		200	14#	9	337.5	804
			3r	0	84	1050
		400

Positive Control	Methyl Methane Sulfonate	15	19#	18	231	413	413*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	55	82	170	102	96
			80	103	232	96
			83	93	223	89
			82	121	237	97
Test Chemical	4-Vinyl-1-cyclohexene diepoxide	25	84	82	446	178	175*
			81	108	419	172	175*
		50	62#	54	513	277	274*
			59	84	480	272	274*
		100	54	53	954	594	590*
			54	46	950	586	590*
		200	15	5	915	2011	1595*
			23	8	825	1179	1595*
		400

Positive Control	Methyl Methane Sulfonate	15	20	15	475	812	700*
Positive Control			26	17	464	587	700*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination