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Study Information
Study Attribute Value
CEBS Accession Number: 002-01522-0008-0000-0
Chemical Name: 4-Vinyl-1-cyclohexene diepoxide
CASRN: 106-87-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 496867
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 52 91 83 54 48
    56 102 72 43
    48r 93 87 61
    63# 108 91.5 48
Test Chemical 4-Vinyl-1-cyclohexene diepoxide 
25         
 45 53 247 184 157*
    48# 68 184.5 129
  
50         
 30 49 305 335 273*
    36# 36 229.5 211
  
100         
 13 8 414 1075 895*
    20 21 418 715
  
200         
 14# 9 337.5 804
    3r 0 84 1050
  
400         
   
Positive Control Methyl Methane Sulfonate 
15         
 19# 18 231 413 413*

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 55 82 170 102 96
    80 103 232 96
    83 93 223 89
    82 121 237 97
Test Chemical 4-Vinyl-1-cyclohexene diepoxide 
25         
 84 82 446 178 175*
    81 108 419 172
  
50         
 62# 54 513 277 274*
    59 84 480 272
  
100         
 54 53 954 594 590*
    54 46 950 586
  
200         
 15 5 915 2011 1595*
    23 8 825 1179
  
400         
   
Positive Control Methyl Methane Sulfonate 
15         
 20 15 475 812 700*
    26 17 464 587

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination