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Study Information
Study Attribute Value
CEBS Accession Number: 002-01523-0001-0000-4
Chemical Name: 4-Vinylcyclohexene
CASRN: 100-40-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 169960_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1013 402 0.397 8.04 25.5 0.000
Test Chemical 4-Vinylcyclohexene 
5         
 50 1031 444 0.431 8.88 25.5 8.519 
16.7       
 50 1039 440 0.423 8.80 25.5 6.714 
50         
 50 1017 451 0.443 9.02 25.5 11.748 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1037 623 0.601 12.46 25.5 51.388
Mitomycin-C 
 0.01      
 5 102 218 2.137 43.60 25.5 438.567
Trend: 1.444        
Probability: 0.074        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1006 396 0.394 7.92 25.5 0.000
Test Chemical 4-Vinylcyclohexene 
5         
 50 1019 434 0.426 8.68 25.5 8.198 
16.7       
 50 1029 433 0.421 8.66 25.5 6.899 
50         
 50 1018 452 0.444 9.04 25.5 12.796 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1019 542 0.532 10.84 25.5 35.123
Cyclophosphamide 
2         
 5 100 187 1.870 37.40 25.5 375.056
Trend: 1.592        
Probability: 0.056