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Study Information
Study Attribute Value
CEBS Accession Number: 002-01523-0001-0000-4
Chemical Name: 4-Vinylcyclohexene
CASRN: 100-40-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 169960_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/07/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1013 402 0.397 8.04 25.5 0.000
Test Chemical 4-Vinylcyclohexene
5         
50 1031 444 0.431 8.88 25.5 8.519
16.7       
50 1039 440 0.423 8.80 25.5 6.714
50         
50 1017 451 0.443 9.02 25.5 11.748
166.7       
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1037 623 0.601 12.46 25.5 51.388
Mitomycin-C
 0.01      
5 102 218 2.137 43.60 25.5 438.567
Trend: 1.444        
Probability: 0.074        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/07/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1006 396 0.394 7.92 25.5 0.000
Test Chemical 4-Vinylcyclohexene
5         
50 1019 434 0.426 8.68 25.5 8.198
16.7       
50 1029 433 0.421 8.66 25.5 6.899
50         
50 1018 452 0.444 9.04 25.5 12.796
166.7       
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.4       
50 1019 542 0.532 10.84 25.5 35.123
Cyclophosphamide
2         
5 100 187 1.870 37.40 25.5 375.056
Trend: 1.592        
Probability: 0.056