| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01523-0002-0000-5 |
| Chemical Name: | 4-Vinylcyclohexene |
| CASRN: | 100-40-3 |
| NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
| NTP Study ID: | 169960_CA |
| Study Result: | Negative |
| Activation | Trial | Trial Call |
|---|---|---|
| No Activation | 1 | Negative |
| Induced Rat Liver S9 | 1_S9 | Negative |
| Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
| Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
| Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
| Test Chemical: | 4-Vinylcyclohexene | 25 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
49.9 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
99.8 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
149.5 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
| Positive Control: | Mitomycin-C | 0.15 | 100 | 8 | 0.080 | 7.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 4.0 | 1 | 0.010 | 1.0 |
| Mitomycin-C | 0.5 | 25 | 5 | 0.200 | 20.0 | 3 | 0.120 | 12.0 | 2 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
| Trend: | 1.239 | 0.434 | 1.158 | ||||||||||||
| Probability: | 0.108 | 0.332 | 0.123 | ||||||||||||
| Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
| Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
| Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
| Test Chemical: | 4-Vinylcyclohexene | 12.5 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
25 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
49.9 | 100 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
99.8 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
| Positive Control: | Cyclophosphamide | 7.5 | 100 | 14 | 0.140 | 11.0 | 5 | 0.050 | 4.0 | 9 | 0.090 | 8.0 | 0 | 0.000 | 0.0 |
| Cyclophosphamide | 37.5 | 25 | 14 | 0.560 | 36.0 | 6 | 0.240 | 16.0 | 8 | 0.320 | 28.0 | 0 | 0.000 | 0.0 | |
| Trend: | 1.472 | 1.348 | 0.635 | ||||||||||||
| Probability: | 0.070 | 0.089 | 0.263 | ||||||||||||