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Study Information
Study Attribute Value
CEBS Accession Number: 002-01525-0013-0000-9
Chemical Name: 5,5-Diphenylhydantoin (phenytoin)
CASRN: 57-41-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 252423_SCE
Study Result: Equivocal


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/04/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.39 ± 0.330
Test Chemical 5,5-Diphenylhydantoin (phenytoin) 
62.5       
 4 4.53 ± 0.393
  
125         
 4 7.88 ± 0.182
  
250         
 4 5.23 ± 1.080
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.58 ± 1.296


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/02/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.40 ± 1.084
Test Chemical 5,5-Diphenylhydantoin (phenytoin) 
25         
 4 6.16 ± 0.682
  
50         
 4 6.93 ± 0.623
  
100         
 4 7.56 ± 1.217
Positive Control Dimethylbenzanthracene 
2.5       
 4 13.69 ± 0.715


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed