Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01530-0001-0000-2 |
Chemical Name: | 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) |
CASRN: | 2608-48-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 073716_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1012 | 394 | 0.389 | 7.88 | 25.5 | 0.000 |
Test Chemical | 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) | 0.03 | 50 | 1017 | 381 | 0.375 | 7.62 | 25.5 | -3.775 |
0.1 | 50 | 1028 | 399 | 0.388 | 7.98 | 25.5 | -0.307 | ||
0.3 | 50 | 1025 | 401 | 0.391 | 8.02 | 25.5 | 0.486 | ||
1 | 50 | 1022 | 405 | 0.396 | 8.10 | 25.5 | 1.786 | ||
3.3 | 0 | 0 | 0 | 0.000 | 0.00 | 35.5 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1026 | 519 | 0.506 | 10.38 | 25.5 | 29.928 |
Mitomycin-C | 0.01 | 5 | 102 | 195 | 1.912 | 39.00 | 25.5 | 391.042 | |
Trend: | 0.495 | ||||||||
Probability: | 0.310 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1031 | 393 | 0.381 | 7.86 | 25.5 | 0.000 |
Test Chemical | 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) | 10 | 50 | 1011 | 420 | 0.415 | 8.40 | 25.5 | 8.984 |
33.3 | 50 | 1013 | 384 | 0.379 | 7.68 | 25.5 | -0.554 | ||
100 | 50 | 1038 | 418 | 0.403 | 8.36 | 25.5 | 5.644 | ||
333.3 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.04 | 50 | 1009 | 654 | 0.648 | 13.08 | 25.5 | 70.041 |
Cyclophosphamide | 2 | 5 | 103 | 186 | 1.806 | 37.20 | 25.5 | 373.742 | |
Trend: | 0.318 | ||||||||
Probability: | 0.375 |